The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me has been implicated in chromatin-associated functions including gene transcriptio...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Kari, Vijayalakshmi, Raul, Sanjay Kumar, Henck, Jana Maria, Kitz, Julia, Kramer, Frank, Kosinsky, Robyn Laura, Übelmesser, Nadine, Mansour, Wael Yassin, Eggert, Jessica, Spitzner, Melanie, Najafova, Zeynab, Bastians, Holger, Grade, Marian, Gaedcke, Jochen, Wegwitz, Florian, Johnsen, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323691/
https://ncbi.nlm.nih.gov/pubmed/30616689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0601-1
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