The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me has been implicated in chromatin-associated functions including gene transcriptio...

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Publicat a:Clin Epigenetics
Autors principals: Kari, Vijayalakshmi, Raul, Sanjay Kumar, Henck, Jana Maria, Kitz, Julia, Kramer, Frank, Kosinsky, Robyn Laura, Übelmesser, Nadine, Mansour, Wael Yassin, Eggert, Jessica, Spitzner, Melanie, Najafova, Zeynab, Bastians, Holger, Grade, Marian, Gaedcke, Jochen, Wegwitz, Florian, Johnsen, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323691/
https://ncbi.nlm.nih.gov/pubmed/30616689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0601-1
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