MHC I Expression Regulates Co-clustering and Mobility of Interleukin-2 and -15 Receptors in T Cells

MHC glycoproteins form supramolecular clusters with interleukin-2 and -15 receptors in lipid rafts of T cells. The role of highly expressed MHC I in maintaining these clusters is unknown. We knocked down MHC I in FT7.10 human T cells, and studied protein clustering at two hierarchic levels: molecula...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Mocsár, Gábor, Volkó, Julianna, Rönnlund, Daniel, Widengren, Jerker, Nagy, Péter, Szöllősi, János, Tóth, Katalin, Goldman, Carolyn K., Damjanovich, Sándor, Waldmann, Thomas A., Bodnár, Andrea, Vámosi, György
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Membranes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944762/
https://ncbi.nlm.nih.gov/pubmed/27410738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.05.044
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