IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies

Interleukin-2 (IL-2) and IL-15 play pivotal roles in T cell activation, apoptosis, and survival, and are implicated in leukemias and autoimmune diseases. Their heterotrimeric receptors share their β- and γ(c)-chains, but have distinct α-chains. Anti–IL-2Rα (daclizumab) therapy targeting cell surface...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Volkó, Julianna, Kenesei, Ádám, Zhang, Meili, Várnai, Péter, Mocsár, Gábor, Petrus, Michael N., Jambrovics, Károly, Balajthy, Zoltán, Müller, Gabriele, Bodnár, Andrea, Tóth, Katalin, Waldmann, Thomas A., Vámosi, György
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800387/
https://ncbi.nlm.nih.gov/pubmed/31570576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901382116
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