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Total Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module

Monoubiquitination of histone H2B plays a central role in transcription activation and is required for downstream histone methylation events. Deubiquitination of H2B by the Spt-Ada-Gcn5 acetyltransferase (SAGA) coactivator complex is regulated by a recently discovered histone mark, phosphorylated H2...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Jbara, Muhammad, Maity, Suman Kumar, Morgan, Michael, Wolberger, Cynthia, Brik, Ashraf
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944388/
https://ncbi.nlm.nih.gov/pubmed/26960207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201600638
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