Generating Bona Fide Mammalian Prions with Internal Deletions

Mammalian prions are PrP proteins with altered structures causing transmissible fatal neurodegenerative diseases. They are self-perpetuating through formation of beta-sheet-rich assemblies that seed conformational change of cellular PrP. Pathological PrP usually forms an insoluble protease-resistant...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Munoz-Montesino, Carola, Sizun, Christina, Moudjou, Mohammed, Herzog, Laetitia, Reine, Fabienne, Chapuis, Jérôme, Ciric, Danica, Igel-Egalon, Angelique, Laude, Hubert, Béringue, Vincent, Rezaei, Human, Dron, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944278/
https://ncbi.nlm.nih.gov/pubmed/27226369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00555-16
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