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A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP
Prions result from a drastic conformational change of the host-encoded cellular prion protein (PrP), leading to the formation of β-sheet–rich, insoluble, and protease-resistant self-replicating assemblies (PrP(Sc)). The cellular and molecular mechanisms involved in spontaneous prion formation in spo...
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| Vydáno v: | J Biol Chem |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7549040/ https://ncbi.nlm.nih.gov/pubmed/32788216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014738 |
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