A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP

Prions result from a drastic conformational change of the host-encoded cellular prion protein (PrP), leading to the formation of β-sheet–rich, insoluble, and protease-resistant self-replicating assemblies (PrP(Sc)). The cellular and molecular mechanisms involved in spontaneous prion formation in spo...

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Vydáno v:J Biol Chem
Hlavní autoři: Munoz-Montesino, Carola, Larkem, Djabir, Barbereau, Clément, Igel-Egalon, Angélique, Truchet, Sandrine, Jacquet, Eric, Nhiri, Naïma, Moudjou, Mohammed, Sizun, Christina, Rezaei, Human, Béringue, Vincent, Dron, Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549040/
https://ncbi.nlm.nih.gov/pubmed/32788216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014738
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