CD8(+) T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles

The mechanisms of viral control and loss of viral control in chronically infected individuals with or without protective HLA class I alleles are not fully understood. We therefore characterized longitudinally the immunological and virological features that may explain divergence in disease outcome i...

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Publicado en:J Virol
Autores principales: Koofhethile, Catherine K., Ndhlovu, Zaza M., Thobakgale-Tshabalala, Christina, Prado, Julia G., Ismail, Nasreen, Mncube, Zenele, Mkhize, Lungile, van der Stok, Mary, Yende, Nonhlanhla, Walker, Bruce D., Goulder, Philip J. R., Ndung'u, Thumbi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Cellular Response to Infection
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944274/
https://ncbi.nlm.nih.gov/pubmed/27194762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00276-16
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