Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein

TRIM28 regulates its target genes at both transcriptional and posttranscriptional levels. Here we report that a TRIM28-TWIST1-EMT axis exists in breast cancer cells and TRIM28 promotes breast cancer metastasis by stabilizing TWIST1 and subsequently enhancing EMT. We find that TRIM28 is highly expres...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wei, Chunli, Cheng, Jingliang, Zhou, Boxv, Zhu, Li, Khan, Md. Asaduzzaman, He, Tao, Zhou, Sufang, He, Jian, Lu, Xiaoling, Chen, Hanchun, Zhang, Dianzheng, Zhao, Yongxiang, Fu, Junjiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944148/
https://ncbi.nlm.nih.gov/pubmed/27412325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29822
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