ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin

The realization, that the androgen receptor (AR) is essential for prostate cancer (PC) even after relapse following androgen deprivation therapy motivated the search for novel types of AR inhibitors. We proposed that targeting AR expression versus its function would work in cells having either wild...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Fleyshman, Daria, Cheney, Peter, Ströse, Anda, Mudambi, Shaila, Safina, Alfiya, Commane, Mairead, Purmal, Andrei, Morgan, Kelsey, Wang, Nicholas J., Gray, Joe, Spellman, Paul T., Issaeva, Natalia, Gurova, Katerina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943693/
https://ncbi.nlm.nih.gov/pubmed/26694952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1127478
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