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Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

Aims: This preclinical study was aimed at determining whether pharmacological targeting of transcription factor NRF2, a master controller of many homeostatic genes, might provide a disease-modifying therapy in the animal model of Parkinson's disease (PD) that best reproduces the main hallmark o...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Lastres-Becker, Isabel, García-Yagüe, Angel J., Scannevin, Robert H., Casarejos, María J., Kügler, Sebastian, Rábano, Alberto, Cuadrado, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943471/
https://ncbi.nlm.nih.gov/pubmed/27009601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6549
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