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Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy

Tauopathies are a group of neurodegenerative disorders where TAU protein is presented as aggregates or is abnormally phosphorylated, leading to alterations of axonal transport, neuronal death and neuroinflammation. Currently, there is no treatment to slow progression of these diseases. Here, we have...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Cuadrado, Antonio, Kügler, Sebastian, Lastres-Becker, Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681345/
https://ncbi.nlm.nih.gov/pubmed/29121589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.10.010
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