Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

Brain iron accumulates in several neurodegenerative diseases and can cause oxidative damage, but mechanisms of brain iron homeostasis are incompletely understood. Patients with mutations in the cellular iron-exporting ferroxidase ceruloplasmin (Cp) have brain iron accumulation causing neurodegenerat...

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Pubblicato in:J Neurochem
Autori principali: Zhao, Liangliang, Hadziahmetovic, Majda, Wang, Chenguang, Xu, Xueying, Song, Ying, Jinnah, H.A., Wodzinska, Jolanta, Iacovelli, Jared, Wolkow, Natalie, Krajacic, Predrag, Weissberger, Alyssa Cwanger, Connelly, John, Spino, Michael, Lee, Michael K., Connor, James, Giasson, Benoit, Harris, Z. Leah, Dunaief, Joshua L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943332/
https://ncbi.nlm.nih.gov/pubmed/26303407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13292
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