Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

Brain iron accumulates in several neurodegenerative diseases and can cause oxidative damage, but mechanisms of brain iron homeostasis are incompletely understood. Patients with mutations in the cellular iron-exporting ferroxidase ceruloplasmin (Cp) have brain iron accumulation causing neurodegenerat...

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Bibliographic Details
Published in:J Neurochem
Main Authors: Zhao, Liangliang, Hadziahmetovic, Majda, Wang, Chenguang, Xu, Xueying, Song, Ying, Jinnah, H.A., Wodzinska, Jolanta, Iacovelli, Jared, Wolkow, Natalie, Krajacic, Predrag, Weissberger, Alyssa Cwanger, Connelly, John, Spino, Michael, Lee, Michael K., Connor, James, Giasson, Benoit, Harris, Z. Leah, Dunaief, Joshua L.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943332/
https://ncbi.nlm.nih.gov/pubmed/26303407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13292
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