Targeting cellular mRNAs translation by CRISPR-Cas9

Recently CRISPR-Cas9 system has been reported to be capable of targeting a viral RNA, and this phenomenon thus raises an interesting question of whether Cas9 can also influence translation of cellular mRNAs. Here, we show that both natural and catalytically dead Cas9 can repress mRNA translation of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Liu, Yuchen, Chen, Zhicong, He, Anbang, Zhan, Yonghao, Li, Jianfa, Liu, Li, Wu, Hanwei, Zhuang, Chengle, Lin, Junhao, Zhang, Qiaoxia, Huang, Weiren
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942795/
https://ncbi.nlm.nih.gov/pubmed/27405721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29652
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