Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated and usually cause few phenotypic changes. Using the engineering principles of synthetic biology, we provided a novel and sta...

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Publicado no:Sci Rep
Main Authors: Zhan, Yonghao, Liu, Yuchen, Lin, Junhao, Fu, Xing, Zhuang, Chengle, Liu, Li, Xu, Wen, Li, Jianfa, Chen, Mingwei, Zhao, Guoping, Huang, Weiren, Cai, Zhiming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635424/
https://ncbi.nlm.nih.gov/pubmed/26541358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16177
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