Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637

Ribonucleic acid interference (RNAi) based on microRNA (miRNA) may provide efficient and safe therapeutic opportunities. However, natural microRNAs can not easily be regulated and usually cause few phenotypic changes. Using the engineering principles of synthetic biology, we provided a novel and sta...

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Foilsithe in:Sci Rep
Main Authors: Zhan, Yonghao, Liu, Yuchen, Lin, Junhao, Fu, Xing, Zhuang, Chengle, Liu, Li, Xu, Wen, Li, Jianfa, Chen, Mingwei, Zhao, Guoping, Huang, Weiren, Cai, Zhiming
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635424/
https://ncbi.nlm.nih.gov/pubmed/26541358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16177
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