Targeting cellular mRNAs translation by CRISPR-Cas9

Recently CRISPR-Cas9 system has been reported to be capable of targeting a viral RNA, and this phenomenon thus raises an interesting question of whether Cas9 can also influence translation of cellular mRNAs. Here, we show that both natural and catalytically dead Cas9 can repress mRNA translation of...

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Опубликовано в: :Sci Rep
Главные авторы: Liu, Yuchen, Chen, Zhicong, He, Anbang, Zhan, Yonghao, Li, Jianfa, Liu, Li, Wu, Hanwei, Zhuang, Chengle, Lin, Junhao, Zhang, Qiaoxia, Huang, Weiren
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942795/
https://ncbi.nlm.nih.gov/pubmed/27405721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29652
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