Targeting cellular mRNAs translation by CRISPR-Cas9

Recently CRISPR-Cas9 system has been reported to be capable of targeting a viral RNA, and this phenomenon thus raises an interesting question of whether Cas9 can also influence translation of cellular mRNAs. Here, we show that both natural and catalytically dead Cas9 can repress mRNA translation of...

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Publicado en:Sci Rep
Autores principales: Liu, Yuchen, Chen, Zhicong, He, Anbang, Zhan, Yonghao, Li, Jianfa, Liu, Li, Wu, Hanwei, Zhuang, Chengle, Lin, Junhao, Zhang, Qiaoxia, Huang, Weiren
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942795/
https://ncbi.nlm.nih.gov/pubmed/27405721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29652
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