Three-dimensional perfused tumour spheroid model for anti-cancer drug screening

OBJECTIVE: To build an in vitro-perfused, three-dimensional (3D) spheroid model based on the TissueFlex system for anti-cancer drug efficacy testing in order to mimic avascular micro-tissues with inherent O(2), nutrient and metabolite gradients, and to provide a more accurate prediction of drug toxi...

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Bibliografiske detaljer
Udgivet i:Biotechnol Lett
Main Authors: Wan, Xiao, Li, Zhaohui, Ye, Hua, Cui, Zhanfeng
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2016
Fag:
Original Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942491/
https://ncbi.nlm.nih.gov/pubmed/27167883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10529-016-2035-1
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