Gene Therapy for MERTK-Associated Retinal Degenerations

MERTK-associated retinal degenerations are thought to have defects in phagocytosis of shed outer segment membranes by the retinal pigment epithelium (RPE), as do the rodent models of these diseases. We have subretinally injected an RPE-specific AAV2 vector, AAV2-VMD2-hMERTK, to determine whether thi...

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Udgivet i:Adv Exp Med Biol
Main Authors: LaVail, Matthew M., Yasumura, Douglas, Matthes, Michael T., Yang, Haidong, Hauswirth, William W., Deng, Wen-Tao, Vollrath, Douglas
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942279/
https://ncbi.nlm.nih.gov/pubmed/26427450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-319-17121-0_65
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