Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis

We have reported that von Hippel-Lindau protein (pVHL) expression is elevated in human and mouse fibrotic lungs and that overexpression of pVHL stimulates fibroblast proliferation. We sought to determine whether loss of pVHL in fibroblasts prevents injury and fibrosis in mice that are treated with b...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Zhou, Qiyuan, Chen, Tianji, Zhang, Wei, Bozkanat, Melike, Li, Yongchao, Xiao, Lei, van Breemen, Richard B., Christman, John W., Sznajder, Jacob I., Zhou, Guofei
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942192/
https://ncbi.nlm.nih.gov/pubmed/26488390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0111OC
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