Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis

We have reported that von Hippel-Lindau protein (pVHL) expression is elevated in human and mouse fibrotic lungs and that overexpression of pVHL stimulates fibroblast proliferation. We sought to determine whether loss of pVHL in fibroblasts prevents injury and fibrosis in mice that are treated with b...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Zhou, Qiyuan, Chen, Tianji, Zhang, Wei, Bozkanat, Melike, Li, Yongchao, Xiao, Lei, van Breemen, Richard B., Christman, John W., Sznajder, Jacob I., Zhou, Guofei
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942192/
https://ncbi.nlm.nih.gov/pubmed/26488390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0111OC
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