Development of an AAV9 coding for a 3XFLAG-TALE(frat#8)-VP64 able to increase in vivo the human frataxin in YG8R mice

Artificially designed transcription activator-like effector (TALE) proteins fused to a transcription activation domain (TAD), such as VP64, are able to activate specific eukaryotic promoters. They thus provide a good tool for targeted gene regulation as a therapy. However, the efficacy of such an ag...

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Bibliografski detalji
Izdano u:Gene Ther
Glavni autori: Chapdelaine, P, Gérard, C, Sanchez, N, Cherif, K, Rousseau, J, Ouellet, D L, Jauvin, D, Tremblay, J P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940929/
https://ncbi.nlm.nih.gov/pubmed/27082765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.36
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