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Development of an AAV9 coding for a 3XFLAG-TALE(frat#8)-VP64 able to increase in vivo the human frataxin in YG8R mice
Artificially designed transcription activator-like effector (TALE) proteins fused to a transcription activation domain (TAD), such as VP64, are able to activate specific eukaryotic promoters. They thus provide a good tool for targeted gene regulation as a therapy. However, the efficacy of such an ag...
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| 出版年: | Gene Ther |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940929/ https://ncbi.nlm.nih.gov/pubmed/27082765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.36 |
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