Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

BACKGROUND: In the SOD1(G93A) mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such a...

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Publicat a:J Neuroinflammation
Autors principals: Trias, Emiliano, Ibarburu, Sofía, Barreto-Núñez, Romina, Babdor, Joël, Maciel, Thiago T., Guillo, Matthias, Gros, Laurent, Dubreuil, Patrice, Díaz-Amarilla, Pablo, Cassina, Patricia, Martínez-Palma, Laura, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940876/
https://ncbi.nlm.nih.gov/pubmed/27400786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0620-9
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