Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

Motoneuron loss and reactive astrocytosis are pathological hallmarks of amyotrophic lateral sclerosis (ALS), a paralytic neurodegenerative disease that can be triggered by mutations in Cu-Zn superoxide dismutase (SOD1). Dysfunctional astrocytes contribute to ALS pathogenesis, inducing motoneuron dam...

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Detalhes bibliográficos
Main Authors: Díaz-Amarilla, Pablo, Olivera-Bravo, Silvia, Trias, Emiliano, Cragnolini, Andrea, Martínez-Palma, Laura, Cassina, Patricia, Beckman, Joseph, Barbeito, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207668/
https://ncbi.nlm.nih.gov/pubmed/22010221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110689108
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