Extracellular ATP and the P2X(7 )receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

BACKGROUND: During pathology of the nervous system, increased extracellular ATP acts both as a cytotoxic factor and pro-inflammatory mediator through P2X(7 )receptors. In animal models of amyotrophic lateral sclerosis (ALS), astrocytes expressing superoxide dismutase 1 (SOD1(G93A)) mutations display...

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Библиографические подробности
Главные авторы: Gandelman, Mandi, Peluffo, Hugo, Beckman, Joseph S, Cassina, Patricia, Barbeito, Luis
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901222/
https://ncbi.nlm.nih.gov/pubmed/20534165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-33
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