P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway

The P2X7 receptor/channel responds to extracellular ATP and is associated with neuronal death and neuroinflammation in spinal cord injury and amyotrophic lateral sclerosis (ALS). Whether activation of P2X7 directly causes motor neuron death is unknown. We found that cultured motor neurons isolated f...

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Hlavní autoři: Gandelman, Mandi, Levy, Mark, Cassina, Patricia, Barbeito, Luis, Beckman, Joseph S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716845/
https://ncbi.nlm.nih.gov/pubmed/23646980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12286
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