The Fas/Fas Ligand Death Receptor Pathway Contributes to Phenylalanine-Induced Apoptosis in Cortical Neurons

Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe). A recent study showed that the mitochondria-mediated...

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Hlavní autoři: Huang, Xiaodong, Lu, Zhaohui, Lv, Zhongwei, Yu, Tingting, Yang, Peirong, Shen, Yongnian, Ding, Yu, Fu, Da, Zhang, Xiaoping, Fu, Qihua, Yu, Yongguo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737091/
https://ncbi.nlm.nih.gov/pubmed/23940767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071553
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