The Fas/Fas Ligand Death Receptor Pathway Contributes to Phenylalanine-Induced Apoptosis in Cortical Neurons

Phenylketonuria (PKU), an autosomal recessive disorder of amino acid metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene, leads to childhood mental retardation by exposing neurons to cytotoxic levels of phenylalanine (Phe). A recent study showed that the mitochondria-mediated...

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Bibliographic Details
Main Authors:	Huang, Xiaodong, Lu, Zhaohui, Lv, Zhongwei, Yu, Tingting, Yang, Peirong, Shen, Yongnian, Ding, Yu, Fu, Da, Zhang, Xiaoping, Fu, Qihua, Yu, Yongguo
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2013
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3737091/ https://ncbi.nlm.nih.gov/pubmed/23940767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071553
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The Fas/Fas Ligand Death Receptor Pathway Contributes to Phenylalanine-Induced Apoptosis in Cortical Neurons

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