Mitochondrial Dysfunction in SOD1(G93A)-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

Mitochondrial dysfunction and oxidative stress contribute to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Recent reports indicate that astrocytes expressing the mutations of superoxide dismutase-1 (SOD1) may contribute to motor neuron injury in ALS. Here, we provide evidence tha...

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Detalhes bibliográficos
Main Authors: Cassina, Patricia, Cassina, Adriana, Pehar, Mariana, Castellanos, Raquel, Gandelman, Mandi, de León, Andrés, Robinson, Kristine M., Mason, Ronald P., Beckman, Joseph S., Barbeito, Luis, Radi, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844766/
https://ncbi.nlm.nih.gov/pubmed/18417691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5308-07.2008
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