Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a decreased mitochondrial respiratory capacity associated to phenotypic changes that cause them to ind...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Bolatto, Carmen, Trías, Emiliano, Gandelman, Mandi, Radi, Rafael, Barbeito, Luis, Cassina, Patricia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318006/
https://ncbi.nlm.nih.gov/pubmed/22509356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034776
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