Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a decreased mitochondrial respiratory capacity associated to phenotypic changes that cause them to ind...

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Detalhes bibliográficos
Main Authors: Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Bolatto, Carmen, Trías, Emiliano, Gandelman, Mandi, Radi, Rafael, Barbeito, Luis, Cassina, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318006/
https://ncbi.nlm.nih.gov/pubmed/22509356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034776
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