Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a decreased mitochondrial respiratory capacity associated to phenotypic changes that cause them to ind...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Bolatto, Carmen, Trías, Emiliano, Gandelman, Mandi, Radi, Rafael, Barbeito, Luis, Cassina, Patricia
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318006/
https://ncbi.nlm.nih.gov/pubmed/22509356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034776
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars