Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

BACKGROUND: In the SOD1(G93A) mutant rat model of amyotrophic lateral sclerosis (ALS), neuronal death and rapid paralysis progression are associated with the emergence of activated aberrant glial cells that proliferate in the degenerating spinal cord. Whether pharmacological downregulation of such a...

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Publicado en:J Neuroinflammation
Main Authors: Trias, Emiliano, Ibarburu, Sofía, Barreto-Núñez, Romina, Babdor, Joël, Maciel, Thiago T., Guillo, Matthias, Gros, Laurent, Dubreuil, Patrice, Díaz-Amarilla, Pablo, Cassina, Patricia, Martínez-Palma, Laura, Moura, Ivan C., Beckman, Joseph S., Hermine, Olivier, Barbeito, Luis
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940876/
https://ncbi.nlm.nih.gov/pubmed/27400786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0620-9
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