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Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates
Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood–brain barrier and therefore cannot restore brain ChE activity in vivo. Our laboratories have studied highly relevant sarin and VX surrogates, which differ from their respective nerve agen...
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| Udgivet i: | Ann N Y Acad Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940271/ https://ncbi.nlm.nih.gov/pubmed/27153507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13053 |
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