Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus

Organophosphate (OP) anticholinesterases cause excess acetylcholine leading to seizures which, if prolonged, result in neuronal damage in the rodent brain. Novel substituted phenoxyalkyl pyridinium oximes have previously shown evidence of penetrating the rat blood-brain barrier (BBB) in in vivo test...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Dail, Mary B, Leach, Charles A, Meek, Edward C, Olivier, Alicia K, Pringle, Ronald B, Green, Carol E, Chambers, Janice E
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Ach'Ase Reactivators and Reduced Hippocampal Op Toxicity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542341/
https://ncbi.nlm.nih.gov/pubmed/30835286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz060
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