Two highly-related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signalling

We identify Bα (PPP2R2A) and Bδ (PPP2R2D), two highly-related members of the B family of regulatory subunits of the protein phosphatase PP2A, as important modulators of TGF-β/Activin/Nodal signalling, which affect the pathway in opposite ways. Knockdown of Bα in Xenopus embryos or mammalian tissue c...

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Bibliographic Details
Published in:Development
Main Authors: Batut, Julie, Schmierer, Bernhard, Cao, Jing, Raftery, Laurel A., Hill, Caroline S., Howell, Michael
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940033/
https://ncbi.nlm.nih.gov/pubmed/18697906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.020842
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