Somatic mutation in PIK3CA is a late event in cervical carcinogenesis

Somatic mutations in cervical intraepithelial neoplasia (CIN) are largely unknown. Here, we profiled 35 cervical carcinomas and 23 CIN grade 2/3 (CIN2/3) for mutations in 48 cancer‐related genes using a Next Generation Sequencing‐based cancer panel. PIK3CA exon 9 was the most frequently mutated locu...

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Detalhes bibliográficos
Publicado no:J Pathol Clin Res
Main Authors: Verlaat, Wina, Snijders, Peter JF, van Moorsel, Marinda IH, Bleeker, Maaike, Rozendaal, Lawrence, Sie, Daoud, Ylstra, Bauke, Meijer, Chris JLM, Steenbergen, Renske DM, Heideman, Daniëlle AM
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939891/
https://ncbi.nlm.nih.gov/pubmed/27499905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cjp2.27
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