Mutations in Antibody Fragments Modulate Allosteric Response Via Hydrogen-Bond Network Fluctuations

A mechanical perturbation method that locally restricts conformational entropy along the protein backbone is used to identify putative allosteric sites in a series of antibody fragments. The method is based on a distance constraint model that integrates mechanical and thermodynamic viewpoints of pro...

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Detaylı Bibliyografya
Yayımlandı:Biophys J
Asıl Yazarlar: Srivastava, Amit, Tracka, Malgorzata B., Uddin, Shahid, Casas-Finet, Jose, Livesay, Dennis R., Jacobs, Donald J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Biophysical Society 2016
Konular:
Proteins
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939758/
https://ncbi.nlm.nih.gov/pubmed/27166802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.03.033
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