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Mutations in Antibody Fragments Modulate Allosteric Response Via Hydrogen-Bond Network Fluctuations
A mechanical perturbation method that locally restricts conformational entropy along the protein backbone is used to identify putative allosteric sites in a series of antibody fragments. The method is based on a distance constraint model that integrates mechanical and thermodynamic viewpoints of pro...
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| Pubblicato in: | Biophys J |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939758/ https://ncbi.nlm.nih.gov/pubmed/27166802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.03.033 |
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