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Decomposing dynamical couplings in mutated scFv antibody fragments into stabilizing and destabilizing effects
Conformational fluctuations within scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamics trajectories. Both perturbation and response profiles are stratified into stabilizing and destabilizing conditions. The linker between the VH and VL domains exhib...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5998336/ https://ncbi.nlm.nih.gov/pubmed/29139290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09268 |
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