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Decomposing dynamical couplings in mutated scFv antibody fragments into stabilizing and destabilizing effects

Conformational fluctuations within scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamics trajectories. Both perturbation and response profiles are stratified into stabilizing and destabilizing conditions. The linker between the VH and VL domains exhib...

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書誌詳細
出版年:J Am Chem Soc
主要な著者: Ettayapuram Ramaprasad, Azhagiya Singam, Uddin, Shahid, Casas-Finet, Jose, Jacobs, Donald J.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998336/
https://ncbi.nlm.nih.gov/pubmed/29139290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09268
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