Thermodynamic stability and flexibility characteristics of antibody fragment complexes

Free energy landscapes, backbone flexibility and residue-residue couplings for being co-rigid or co-flexible are calculated from the minimal Distance Constraint Model (mDCM) on an exploratory dataset consisting of VL, scFv and Fab antibody fragments. Experimental heat capacity curves are reproduced...

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Detaylı Bibliyografya
Yayımlandı:Protein Pept Lett
Asıl Yazarlar: Li, Tong, Verma, Deeptak, Tracka, Malgorzata B., Casas-Finet, Jose, Livesay, Dennis R., Jacobs, Donald J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667953/
https://ncbi.nlm.nih.gov/pubmed/23855672
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