Thermodynamic stability and flexibility characteristics of antibody fragment complexes

Free energy landscapes, backbone flexibility and residue-residue couplings for being co-rigid or co-flexible are calculated from the minimal Distance Constraint Model (mDCM) on an exploratory dataset consisting of VL, scFv and Fab antibody fragments. Experimental heat capacity curves are reproduced...

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Vydáno v:Protein Pept Lett
Hlavní autoři: Li, Tong, Verma, Deeptak, Tracka, Malgorzata B., Casas-Finet, Jose, Livesay, Dennis R., Jacobs, Donald J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667953/
https://ncbi.nlm.nih.gov/pubmed/23855672
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