Laminopathies disrupt epigenomic developmental programs and cell fate

The nuclear envelope protein lamin A is encoded by the lamin A/C (LMNA) gene, which can contain missense mutations that cause Emery-Dreifuss muscular dystrophy (EDMD) (p.R453W). We fused mutated forms of the lamin A protein to bacterial DNA adenine methyltransferase (Dam) to define euchromatic-heter...

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Bibliographic Details
Published in:Sci Transl Med
Main Authors: Perovanovic, Jelena, Dell’Orso, Stefania, Gnochi, Viola F., Jaiswal, Jyoti K., Sartorelli, Vittorio, Vigouroux, Corinne, Mamchaoui, Kamel, Mouly, Vincent, Bonne, Gisèle, Hoffman, Eric P.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939618/
https://ncbi.nlm.nih.gov/pubmed/27099177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4991
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