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Laminopathies disrupt epigenomic developmental programs and cell fate
The nuclear envelope protein lamin A is encoded by the lamin A/C (LMNA) gene, which can contain missense mutations that cause Emery-Dreifuss muscular dystrophy (EDMD) (p.R453W). We fused mutated forms of the lamin A protein to bacterial DNA adenine methyltransferase (Dam) to define euchromatic-heter...
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| Publicado no: | Sci Transl Med |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939618/ https://ncbi.nlm.nih.gov/pubmed/27099177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4991 |
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