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Adaptive Phase I Clinical Trial Design Using Markov Models for Conditional Probability of Toxicity
Many phase I trials in oncology involve multiple dose administrations on the same patient over multiple cycles, with a typical cycle lasting three weeks and having about six cycles per patient with a goal to find the maximum tolerated dose (MTD) and study the dose-toxicity relationship. A patient�...
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| Publicado no: | J Biopharm Stat |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939077/ https://ncbi.nlm.nih.gov/pubmed/26098782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2015.1052492 |
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