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Adaptive Phase I Clinical Trial Design Using Markov Models for Conditional Probability of Toxicity
Many phase I trials in oncology involve multiple dose administrations on the same patient over multiple cycles, with a typical cycle lasting three weeks and having about six cycles per patient with a goal to find the maximum tolerated dose (MTD) and study the dose-toxicity relationship. A patient�...
Kaydedildi:
| Yayımlandı: | J Biopharm Stat |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939077/ https://ncbi.nlm.nih.gov/pubmed/26098782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2015.1052492 |
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