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Phase I/II trial design when response is unobserved in subjects with dose-limiting toxicity

We propose a Phase I/II trial design in which subjects with dose-limiting toxicity are not followed for response, leading to three possible outcomes for each subject: dose-limiting toxicity, absence of therapeutic response without dose-limiting toxicity, and presence of therapeutic response without...

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Autori principali: Braun, Thomas M., Kang, Shan, Taylor, Jeremy M. G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096077/
https://ncbi.nlm.nih.gov/pubmed/23117408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280212464541
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