Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine

Zidovudine (AZT) remains the mainstay of antiretroviral therapy against HIV in resource-poor countries; however, its use is frequently associated with hepatotoxicity. Not all HIV patients on AZT develop hepatotoxicity, and the determining factors are unclear. Alcohol consumption and cigarette smokin...

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Bibliografiske detaljer
Udgivet i:Toxicol In Vitro
Main Authors: Ghare, Smita S., Donde, Hridgandh, Chen, Wei-Yang, Barker, David F., Gobejishvilli, Leila, McClain, Craig J., Barve, Shirish S., Joshi-Barve, Swati
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938746/
https://ncbi.nlm.nih.gov/pubmed/27238871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2016.05.013
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