Tumor-infiltrating HLA-matched CD4(+) T cells retargeted against Hodgkin and Reed–Sternberg cells

Hodgkin lymphoma (HL) presents with a unique histologic pattern. Pathognomonic Hodgkin and Reed–Sternberg (HRS) cells usually account for less than 1% of the tumor and are embedded in a reactive infiltrate mainly comprised of CD4(+) T cells. HRS cells induce an immunosuppressive microenvironment and...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Rengstl, Benjamin, Schmid, Frederike, Weiser, Christian, Döring, Claudia, Heinrich, Tim, Warner, Kathrin, Becker, Petra S. A., Wistinghausen, Robin, Kameh-Var, Sima, Werling, Eva, Billmeier, Arne, Seidl, Christian, Hartmann, Sylvia, Abken, Hinrich, Küppers, Ralf, Hansmann, Martin-Leo, Newrzela, Sebastian
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938355/
https://ncbi.nlm.nih.gov/pubmed/27471632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1160186
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